24 Oct

nancy sullivan nih

We are using these tools to dissect the molecular events underlying Ebola GP interactions within the host. Office of Technology Transfer, Office of Intramural Research, National Institutes of Health, 6011 Executive Blvd, Suite 325, Rockville, MD 20852 | Phone: 301-496-7057, Find any text anywhere within the abstract. Hensley LE, Mulangu S, Asiedu C, Johnson J, Honko AN, Stanley D, Fabozzi G, Nichol ST, Ksiazek TG, Rollin PE, Wahl-Jensen V, Bailey M, Jahrling PB, Roederer M, Koup RA, Sullivan NJ.   Nat Med. Epub 2014 Nov 26. 2014 Oct;20(10):1126-9. doi: 10.1038/nm.3702. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Epub 2016 Feb 25. Structural and molecular basis for Ebola virus neutralization by protective human antibodies. President Obama Visits Ebola Vaccine Lab as Women Make History. Dr. Nancy J. Sullivan and colleagues at NIH’s National Institute of Allergy and Infectious Diseases (NIAID) Vaccine Research Center developed a similar monoclonal antibody called mAb114 that was derived from the blood of an Ebola survivor. We have also obtained blood samples from individuals who survived the 1995 Ebola outbreak in Kikwit and are conducting a cross-sectional study to define antibody and T-lymphocyte responses associated with survival from infection. We are currently expanding these studies to define the relative or cooperative roles of antibodies and T lymphocytes for immune protection against Ebola. Therefore, vaccine studies are critically important for protection against infection. Dr. Sullivan’s long-term commitment to Ebola research has resulted in discovery of both vaccines and therapies. Chimpanzee Adenovirus Vector Ebola Vaccine. Credit: NIH. 2017 Mar 9;376(10):928-938. doi: 10.1056/NEJMoa1410863. Nancy Jean Sullivan is an American cell biologist researching filovirus immunology and vaccine development. Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody. Therefore, vaccine studies are critically important for protection against infection. All Inventions from Dr. Nancy Sullivan . Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates. Dr. Sullivan is a tenured Senior Investigator and Chief of the Biodefense Research Section at the Vaccine Research Center, a division of the National Institute of Allergy and Infectious Diseases (NIAID) at the NIH. 2003;424(6949):681-4. Our laboratory is also interested the basic biology underlying Ebola virus pathogenesis, virus-host interactions, and inhibition of virus replication. It can bind to the virus and prevent it from entering cells. Geisbert TW, Bailey M, Geisbert JB, Asiedu C, Roederer M, Grazia-Pau M, Custers J, Jahrling P, Goudsmit J, Koup R, Sullivan NJ. 2011;17(9):1128-31. Get the latest public health information from CDC. Dr. Sullivan’s long-term commitment to Ebola research has resulted in discovery of both vaccines and therapies. Dr. Sullivan is a leader in the field and has personally conducted many of the most critical experiments. A second area of study is the analysis of vaccine-induced immune responses to better understand the mechanisms of immune protection against natural Ebola virus infection. Science. Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge. Studies with the antibody demonstrated that the most potent mechanism of antibody protection is through high affinity, low pH-stable binding that blocks a critical Ebola interaction with its intracellular receptor, Neimann-Pick C1. By using a novel gene-based prime boost vaccine, Dr. Sullivan and her team were the first to demonstrate vaccine protection against Ebola infection in primates. The Ebola vaccine developed by Dr. Nancy Sullivan at NIAID is a Women’s History Month highlight: women developed the vaccine and coordinated and led the clinical trial, and a woman was the first volunteer to receive the vaccine. Credit: NIH. 2010;84(19):10386-94. We are using the nonhuman primate model for this study. 2003 Aug 7;424(6949):681-4. Vector choice determines immunogenicity and potency of genetic vaccines against Angola Marburg virus in nonhuman primates. e.g. She conducted her doctoral thesis in the laboratory of Dr. Joe Sodroski, where her work demonstrated that primary HIV isolates exhibit resistance to antibody neutralization due to occlusion of the coreceptor binding site on gp120. This was followed by her discovery of a single shot vaccine that provided more immediate protection, making it a very practical vaccine that could be used in the face of an acute Ebola epidemic. We have initiated a prospective study of more than 200 subjects in an Ebola-endemic region of West Africa to determine genetic and immunological factors mediating protection against Ebola infection. Ebola and Marburg viruses have been identified as the cause of several highly lethal outbreaks of hemorrhagic fever for which there is no treatment or cure. We have also obtained blood samples from individuals who survived the 1995 Ebola outbreak in Kikwit and are conducting a cross-sectional study to define antibody and T-lymphocyte responses associated with survival from infection. By using a novel gene-based prime boost vaccine, Dr. Sullivan and her team were the first to demonstrate vaccine protection against Ebola infection in primates. We have shown that CD8+ cells are required for rAd Ebola vaccine protection and that the level of vaccine-induced antibodies correlates with protection but does not mediate protective responses when delivered by passive transfer. This antibody will undergo Phase I clinical trials in 2017 to support stockpiling in preparation for use in future Ebola outbreaks. Dr. Sullivan is a leader in the field and has personally conducted many of the most critical experiments. N Engl J Med. We are currently expanding these studies to define the relative or cooperative roles of antibodies and T lymphocytes for immune protection against Ebola. Her work on filovirus immunology and vaccine development is widely considered as one of the very best in the field despite the difficulties of conducting research under highly specialized BSL-4 containment conditions. More recently, Dr. Sullivan and her team discovered a potently protective monoclonal antibody, mAb114, from a human Ebola survivor that completely rescues Ebola-infected primates, even when given as a monotherapy several days after their Ebola exposure. Evaluation of immune responses in survivors of natural Ebola infection will help to elucidate immune mechanisms of protection, especially memory responses that are critical in a prophylactic vaccine. Nancy Sullivan, Ph.D., is the Chief of the Biodefense Research Section (BRS). Viral Pathogenesis Laboratory. 4 Memorial Drive, Room 228BBethesda, MD 20814. This was followed by her discovery of a single shot vaccine that provided more immediate protection, making it a very practical vaccine that could be used in the face of an acute Ebola epidemic. The vaccines are currently being tested in human trials conducted by the VRC Clinical Trials Core Laboratory in Bethesda, Maryland, and Makerere University in Uganda. Corti D, Misasi J, Mulangu S, Stanley DA, Kanekiyo M, Wollen S, Ploquin A, Doria-Rose NA, Staupe RP, Bailey M, Shi W, Choe M, Marcus H, Thompson EA, Cagigi A, Silacci C, Fernandez-Rodriguez B, Perez L, Sallusto F, Vanzetta F, Agatic G, Cameroni E, Kisalu N, Gordon I, Ledgerwood JE, Mascola JR, Graham BS, Muyembe-Tamfun JJ, Trefry JC, Lanzavecchia A, Sullivan NJ. Demonstration of cross-protective vaccine immunity against an emerging pathogenic Ebolavirus Species. Evaluation of immune responses in survivors of natural Ebola infection will help to elucidate immune mechanisms of protection, especially memory responses that are critical in a prophylactic vaccine. 2016 Mar 18;351(6279):1343-6. doi: 10.1126/science.aad6117. Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates. |   Get the latest research information from NIH. As a result, this vaccination schedule is now standard in the field of Ebola vaccine research, where one of the lead Ebola vaccine candidates, ChAd3-EBOV, has been advanced to Phase I/II and III human clinical trials. Sullivan NJ, Geisbert TW, Geisbert JB, Xu L, Yang ZY, Roederer M, Koup RA, Jahrling PB, Nabel GJ. 2010;6(5):e1000904. 2016 Mar 18;351(6279):1339-42. doi: 10.1126/science.aad5224. Demonstration of cross-protective vaccine immunity against an emerging pathogenic Ebolavirus Species. Our goal with these studies is to identify points in the Ebola virus replication cycle that are vulnerable antiviral and neutralization targets. Epub 2014 Sep 7. She is a senior investigator and chief of the biodefense research section at the Vaccine Research Center. Our laboratory is also interested the basic biology underlying Ebola virus pathogenesis, virus-host interactions, and inhibition of virus replication. The Biodefense Research Section (BRS) has developed highly effective vaccine strategies for Ebola virus infection in non-human primates. Nature. Science. More recently, Dr. Sullivan and her team discovered a potently protective monoclonal antibody, mAb114, from a human Ebola survivor that completely rescues Ebola-infected primates, even when given as a monotherapy several days after their Ebola exposure. Nat Med. Following her work on HIV, Dr. Sullivan pursued postdoctoral training under the guidance of Dr. Gary Nabel, studying the mechanisms of Ebola virus pathogenesis and immune protection. Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates. Sullivan NJ, Geisbert TW, Geisbert JB, Xu L, Yang ZY, Roederer M, Koup RA, Jahrling PB, Nabel GJ. By Michele Lyons. We identified durable antigen-specific T-cell responses in these subjects and also isolated and purified monoclonal antibodies from the B cells of these subjects. Development of a preventive vaccine for Ebola virus infection in primates. She conducted her doctoral thesis in the laboratory of Dr. Joe Sodroski, where her work demonstrated that primary HIV isolates exhibit resistance to antibody neutralization due to occlusion of the coreceptor binding site on gp120. 2000 Nov 30;408(6812):605-9. Dr. Sullivan’s innovative and specialized work on filovirus immunology is recognized worldwide and has consistently been the source of novel observations that have contributed to critical advancements in the field. CD8+ cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates. As a result, this vaccination schedule is now standard in the field of Ebola vaccine research, where one of the lead Ebola vaccine candidates, ChAd3-EBOV, has been advanced to Phase I/II and III human clinical trials. Vector choice determines immunogenicity and potency of genetic vaccines against Angola Marburg virus in nonhuman primates. Her team discovered the monoclonal antibody, mAb114 Education. Dr. Sullivan’s innovative and specialized work on filovirus immunology is recognized worldwide and has consistently been the source of novel observations that have contributed to critical advancements in the field. Sullivan NJ, Hensley L, Asiedu C, Geisbert TW, Stanley D, Johnson J, Honko A, Olinger G, Bailey M, Geisbert JB, Reimann KA, Bao S, Rao S, Roederer M, Jahrling PB, Koup RA, Nabel GJ. Sullivan NJ, Sanchez A, Rollin PE, Yang ZY, Nabel GJ. A second area of study is the analysis of vaccine-induced immune responses to better understand the mechanisms of immune protection against natural Ebola virus infection. Any part of the E#. Following her work on HIV, Dr. Sullivan pursued postdoctoral training under the guidance of Dr. Gary Nabel, studying the mechanisms of Ebola virus pathogenesis and immune protection. View additional Principal Investigators in Immunology, View additional Principal Investigators in Molecular Biology and Biochemistry, View additional Principal Investigators in Virology, This page was last updated on June 27th, 2017, Presidential Early Career Award for Scientists and Engineers (PECASE), National Medal of Technology & Innovation, Samuel J. Heyman Service to America Medals, Advancing Computational and Structural Biology, Uncovering New Opportunities for Natural Products, Unlocking the Potential of RNA Biology and Therapeutics, Tenure-Track/Tenure-Eligible Investigator, NCI-DCEG, Tenure-track, tenure-eligible investigator, NLM, Nurturing the Next Generation of Clinical Researchers.

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